Revisiting basics: theoretically-grounded interesting research that addresses challenges that matter

Four Challenges That Global Health Networks Face

Global health networks, webs of individuals and organizations with a shared concern for a particular condition, have proliferated over the past quarter century. They differ in their effectiveness, a factor that may help explain why resource allocations vary across health conditions and do not correspond closely with disease burden. Drawing on findings from recently concluded studies of eight gl...

Dark Chocolate and Metabolic Syndrome; Do Polyphenols All that Matter?

Methods That Matter in Digital Design Research

Theories and analytical perspectives are linked to methods. The discussion of the methods used to capture the complexities of practices with a focus on social, cultural and economic layers (Jordan and Henderson 1994; Wagner 1994; Sjöberg 1996; Newman 1998) represents an important resource for a discussion of designers’ interpretative work with both traditional and new experimental methods. In p...

MicroRNAs that target RGS5

Objective(s):An earlier meta-analysis on gene expression data derived from four microarray, two cDNA library, and one SAGE experiment had identified RGS5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (TM) cells by all studies. RGS5 encodes regulator of G-protein signaling-5. The TM tissue is the route of aqueous fluid outflow, and is r...

Theoretically Grounded Conversational Interfaces to Digital Information

This paper introduces a general methodology for the development and study of conversational systems. Closer coupling of linguistic and psycholinguistic theories about dialogue with the development of dialogue systems allows each to inform the other more fully. Three activities support our goals. We develop theories through the empirical investigation of dialogue in conversational settings. We u...